Professor & Plant Pathologist
- College of Natural and Agricultural Sciences
- Plant Pathology and Microbiology
National University of Singapore
- PhD Plant Molecular Biology 1990
- Australian National University
- MSc Plant Virology 1985
- Fudan University
- BSc Plant Pathology 1982
- Anhui Agricultural University
2006 American Association for the Advancement of Science, Agriculture,Food & Renewable Resources
2001 State-of-the-Art Lecturer, American Society for Virology
2001 Elected Member, Asia-Pacific International Molecular Biology Network
Gene silencing through a targeted degradation of RNA molecules, or RNA silencing, represents a novel cellular pathway encoded by diverse eukaryotic organisms. My lab studies the mechanisms and biological functions of RNA silencing by analyzing the complex interactions between RNA silencing and viruses in both the plant and animal systems.
Li HW, Li WX and Ding SW. 2002. Induction ans suppression of RNA silencing by an animal virus. Science 296: 1319-1321 (front cover).
Guo HS and Ding SW. 2002. A viral protein inhibits the long-range signaling activity of the gene silencing signal. EMBO J 21:398-407.
Mlotshwa S, Voinnet V, Mette F, Matzke M, Vaucheret V, Ding SW, Pruss G, Vance VB. 2002. RNA silencing and the mobile silencing signal. Plant Cell. In press.
Li WX and Ding SW. 2001. Viral suppressors of RNA silencing. Curr Opin Biotechnol
Ji LH and Ding SW. 2001. The suppressor of transgene RNA silencing encoded by cucumber mosaic virus interferes with salicylic acid-mediated virus resistance. Mol Plant-Microbe Interact 14:715-724.
Ding SW. 2000. RNA silencing. Curr. Opin. Biotech.11:152-156.
Lucy, AP, Guo, HS, Li WX and Ding SW. 2000. Suppression of post-transcriptional gene silencing by a plant viral protein localized in the nucleus. EMBO J 19:1672-1680.
Li HW, Lucy AP, Guo HS, Li WX, Ji LH, Wong SM and Ding SW. 1999. Strong host resistance targeted against a viral suppressor of the plant gene silencing defense mechanism. EMBO J 18:2683-2691.
Brigneti G, Voinnet O, Li WX, Ji LH, Ding SW and Baulcombe DC. 1998. Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana. EMBO J 17:6739-6746.
Xin HW, Ji LH, Scott SW, Symons RH and Ding SW. 1998. Ilarviruses encode a cucumovirus-like 2b gene that is absent in other genera within the Bromoviridae. J.Virol. 72, 6956-6959.