Individual Listing

2115 BIOLOGICAL SCI
University of California
Riverside, CA 92521

Sladek, Frances M

Professor of Cell Biology

College of Natural and Agricultural Sciences

Cell Biology & Neuroscience


Biography

Research Specialization - We use molecular, cellular and biochemical techniques to decipher the molecular mechanism by which a certain liver-enriched transcription factor, hepatocyte nuclear factor 4 (HNF4), controls the expression of a variety of genes, including those involved in cholesterol, fatty acid and glucose metabolism as well as detoxification processes. HNF4 is essential for the development of a wide variety of organisms and has been directly linked to several human diseases, including diabetes, hemophilia and hepatitis B infections. HNF4 is a member of the nuclear receptor super family of ligand-dependent transcription factors.

Degrees

BA Biochemistry 1979

Princeton University

MSc Molecular Biophysics 1981

Yale University

PhD Molecular Biophysics & Biochemistry 1988

Yale University

Awards

2009 Faculty of 1000, Most interesting paper Biology
American Cancer Society Grant Review Panel


Research Area

Molecular endocrinology

Publications

1999 Sladek, F. M., M. D. Ruse, Jr., L. Nepomuceno, S-M Huang, M. R. Stallcup. Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4a1. Molecular and Cellular Biology 19:6509-6522.

1999 Sladek, F. M. and S. Seidel. Hepatotyte nuclear factor 4a. In: Nuclear Receptors and Genetic Disease (T.P. Burris & E. McCabe, eds.), Academic Press, London.

1999 Maeda, Y., M.D. Ruse, Jr. and F.M. Sladek. "A ligand for orphan receptor HNF4a?" In: American Association for Cancer Research Special Conference on "The Steroid Receptor Superfamily," Indian Wells, CA.