Individual Listing

4119A GENOMICS BUILDING
University of California
Riverside, CA 92521

Bailey-Serres, Julia

Professor of Genetics & Geneticist

College of Natural and Agricultural Sciences

Botany & Plant Sciences


Biography

Current research projects include the following: (1) Evaluation of the role of signal transduction processes that underlie the sensing and response to oxygen deprivation. Our studies have shown that forward and negative feedback regulation of signaling through the Rop GTPase is necessary for controlled expression of alcohol dehydrogenase (ADH) in response to low oxygen. We are evaluating the role of fluxes in cytosolic calcium and production of hydrogen peroxide in this signaling system. (2) Evaluation of the regulation of mRNA translation in response to stress. RNA blot and DNA microarray studies have shown that mRNAs are differentially translated in response to oxygen deprivation and water deficit. We are studying the role of specific mRNA sequences and translation factors in the regulation of mRNA translation. (3) Evaluation of the structure and function of plant ribosomes. We have characterized a heterogeneous complex of 12 kDa phosphoproteins (P0, P1, P2 and P3) of the large ribosomal subunit. Current studies address the biological significance of ribosomal protein heterogeneity. We are also characterizing the plant ribosome using proteomic technologies. (4) Development of methods for isolation of polyribsomal mRNA from specific cell types for use in DNA microarray analyses.

Degrees

BS Biology 1981

University of Utah

PhD Plant Molecular Biology 1986

University of Edinburgh

Awards

2009 World Technology Network, Nominee & Finalist
2005 American Association for the Advancement of Science, Biological Sciences
2002 Outstanding Faculty Mentor Chancellor's Award for Excelence in Undergraduate Research
1990-91 University of California Affirmative Action Career Development Award


Research Area

My research focuses on mechanisms of signal transduction and gene regulation that promote plant response and adaptation to unfavorable environmental conditions. Plants respond to many environmental stimuli including light, temperature extremes, water availability, soil minerals, and air pollution (ozone). Our studies have shown that sub-optimal growth conditions typically result in changes in protein synthesis that result from increased regulation of mRNA translation. Several current projects focus on the responses of Arabidopsis, a model plant species. Our research philosophy is to rapidly use knowledge gained from molecular-genetic analyses with Arabidopsis to further our understanding of the responses of crop plants, such as corn and rice.

Publications

Manjunath, S., Williams, A.J., and Bailey-Serres, J. (1999) Oxygen deprivation stimulates Ca2+-mediated phosphorylation of mRNA cap-binding protein eIF4E in maize roots. Plant J. 19(1):21-30.

Szick-Miranda, K and Bailey-Serres (2001) Regulated heterogeneity in 12-kDa P-protein phosphorylation and composition of ribosomes in maize (Zea mays L.). J. Biol. Chem. 276(14):10921-10928.

Barakat, A., Szick-Miranda, K., Chang, I.-F., Guyot, R. Blanc, G., Cooke, R., Delseny R. and Bailey-Serres J. (2001) The organization of cytoplasmic ribosomal protein genes in the Arabidopsis genome. Plant Physiol. 127: 398-416.

Baxter-Burrell, A. Yang, Z., Springer, P.S. and Bailey-Serres (2002) RopGAP4-dependent Rop GTPase rheostat control of Arabidopsis oxygen deprivation tolerance. Science 296(5575):2026-2028.

Kawaguchi R. and Bailey-Serres J. (2002) Regulation of translational initiation in plants. Current Opinion in Plant Biology. 5:460-465.

Kawaguchi R and Bailey-Serres J (2002) Regulation of translational initiation in plants. Curr Opin Plant Bio 5: 460-465.

Kawaguchi R, Williams AJ, Bray EA and Bailey-Serres J (2003) Water-deficit-induced translational control in Nicotiana tabacum. Plant Cell and Env 26: 221-229.

Williams AJ, Werner-Fraczek J, Chang I-F and Bailey-Serres, J (2003) Regulated Phosphorylation of 40S Ribosomal Protein S6 in Root Tips of Maize. Plant Physiol. 132: 2086-2097.

Williams AJ, Werner-Fraczek J, Chang I-F and Bailey-Serres, J (2003) Regulated Phosphorylation of 40S Ribosomal Protein S6 in Root Tips of Maize. Plant Physiol. 132: 2086-2097.

Williams AJ, Werner-Fraczek J, Chang I-F and Bailey-Serres, J (2003) Regulated Phosphorylation of 40S Ribosomal Protein S6 in Root Tips of Maize. Plant Physiol. 132: 2086-2097.

Kawaguchi R, Girke T, Bray EA, and Bailey-Serres J (2004) Differential mRNA translation contributes to gene regulation under non-stress and dehydration stress conditions in Arabidopsis thaliana. Plant Journal 38: 823-839.

Chang, I.F., Szick-Miranda, K., Pan, S. and J. Bailey-Serres. 2005. Proteomic characterization of evolutionarily conserved and variable proteins of Arabidopsis thaliana cytosolic ribosomes. Plant Physiology. 137(3):848-862. Impact factor: 6.114

Kawaguchi, R. and J. Bailey-Serres. 2005. mRNA sequence features responsible for translational regulation in Arabidopsis. Nucleic Acids Research. 33(3):955-965. Impact factor: 7.552.

Horan, K., Lauricha, J., Bailey-Serres, J., Raikhel, N. and T. Girke. 2005. Genome Cluster Database: A sequence family analysis platform for Arabidopsis and Oryza sativa. Plant Physiology. 138:47-54. Impact factor: 6.114.

Zanetti, M.E., Chang, I.-F., Gong, F.-C., Galbraith, D.W., J. Bailey-Serres. 2005. Immuno-affinity purification of polyribosomal complexes of Arabidopsis for global analysis of gene expression. Plant Physiology. 138:624-635. Impact factor: 6.114.

Branco-Price, C., Kawaguchi, R., Ferriera, R. and J. Bailey-Serres. 2005. Genome-wide analysis of transcript abundance and translation in Arabidopsis seedlings subjected to oxygen deprivation. Annals of Botany 96:647-660. Impact factor: 2.665.

Fukao, T., Xu, K., Ronald, P.C. and Bailey-Serres, J. 2006. A variable cluster of ethylene responsive-like factors (ERFs) regulates developmental and metabolic acclimation responses to submergence. Plant Cell. 18(8):2021-2034. Impact factor: 11.088

Xu, K., Xu, K., Fukao, T., Canalas, P., Maghirang-Rodriguez, R., Heuer, S., Ismail, A., Bailey-Serres, J., Ronald, P.C., Mackill, D.J. 2006. Sub1A encodes an ethylene responsive-like factor that confers submergence tolerance to rice. Nature. 442:705-708. Impact factor: 29.273.

Mittler, R., Harper, J., Gollery, M., Cushman, J., Mittler, T., Girke, T., Zhu, J.-K., Bailey-Serres, J. and R. Mitter. 2006. What Makes Species Unique? The Contribution of Proteins with Obscure Features. Genome Biology, 7(7)R:57-64

Bailey-Serres, J. and R. Chang. 2005. Sensing and signalling in response to oxygen deprivation in plant cells and other organisms. Annals of Botany. 96:507-518. [Invited contribution – Refereed] Impact factor: 2.665.

Bailey-Serres, J. and R. Mittler. 2006. The roles of reactive oxygen species in plant cells. Plant Physiology (Special Issue on Reactive Oxygen Species, June 2006, Bailey-Serres and Mittler, Guest Editors). 141(2):311. [Invited contribution – Non-refereed] Impact factor: 6.114