Individual Listing

3119A GENOMICS BUILDING
University of California
Riverside, CA 92521

Cutler, Sean

Asst Prof of Plant Cell Biology & Asst Plant Cell Biologist

College of Natural and Agricultural Sciences

Botany & Plant Sciences


Biography

 

Former Institution

University of Toronto, Toronto Canada

Degrees

Phd biology 2001

Stanford University

Awards

Canadian Research Chair in Functional Genomics, 2006


Research Area

Research in the Cutler lab is focused on two interrelated research interests– the use of chemical genetics to identify new factors that regulate Arabidopsis cell expansion and the analysis and exploitation of natural variation using small molecules. Both of these goals have been pursued in parallel using a collection of ~1000 small molecule cell expansion inhibitors that the lab identified in several small molecule screens for new inhibitors of etiolated hypocotyl cell expansion.

Publications

1. Cutler, S.R., Ghassimian, M., Cooney, S., McCourt, P. 1996. A protein farnesyl transferase involved in ABA transduction in Arabidopsis. Science. Vol. 273: p.1239-1241. (Refereed)

2. Dublois, P., Cutler, S.R., Belzile, F.J. 1998. Regional insertional mutagenesis on chromosome-III of Arabidopsis thaliana using the maize Ac element. Plant Journal. Vol. 13: p.141-151. 11p. (Refereed)

3. Taylor, N.G., Scheible, W.R., Cutler, S., Somerville, C.R., Turner, S.R. 1999. The irregular xylem3 locus of Arabidopsis encodes a cellulose synthase required for secondary cell wall synthesis. Plant Cell. Vol. 11: p.769-779. 11p. (Refereed)

4. Cutler, S.R., Griffitts, J.S., Somerville, C.R. 2000. Random GFP::cDNA fusions enable visualization of Arabidopsis subcellular structures at a high frequency. Proceedings of the National Academy of Sciences. Vol. 97(7): p.3718-3723. 6p. (Refereed)

5. Ghassemian, M., Nambara, E., Cutler, S., Kawaide, H., Kawaide, H., Kamiya, Y., McCourt, P. 2000. Regulation of abscisic acid signaling by the ethylene response pathway in Arabidopsis. Plant Cell. Vol. 12: p.1117-1126. 10p. (Refereed)

6. Cutler, S.R., Ehrhardt, D.W. 2002. Polarized cytokinesis in vacuolate cells of Arabidopsis. Proceedings of the National Academy of Sciences . Vol. 99(5): p.2812-2817. 6p. (Refereed)

7. Cutler, S.R., Sommerville, C.R. 2005. Imaging plant cell death: GFP-Nit1 aggregation marks an early step of wound and herbicide induced cell death. BMC Plant Biology. Vol. 5: 4p. (Refereed)

8. Burns, A., Kwok, T., Howard, A., Houston, J., Chan, A., Cutler, S.R., McCourt, P.M., Roy, P.J. 2006. High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans. Nature Protocols. Vol. 1: 4 p.1906-1914. (Refereed)

9. Kwok, T.C., Ricker, N., Fraser, R., Chan, A.W., Burns, A., Stanley, E.F., McCourt, P.M., Cutler, S.R., Roy, P.J. 2006. A small molecule screen in C. elegans yields a new calcium channel antagonist. Nature. Vol. 44: p.91-95. 5p. (Refereed)

10. Austin, R.S., Provart, N.J., Cutler, S.R. 2007. C-terminal motif prediction in eukaryotic proteomes using comparative genomics and statistical over-representation across protein families. BMC Genomics. Vol. 8: p.191-207. 16p. (Refereed)

11. DeBolt, S., Gutierrez, R., Ehrhardt, D.W., Melo, C.V., Ross, L., Cutler, S.R., Somerville, C.R., Bonetta, D. 2007. Morlin, an inhibitor of cortical microtubule dynamics and cellulose synthase movement. PNAS. Vol. 104: 14 p.5854-5859. (Refereed)

12. Chakraborty, A., Sain, M., Kortschot, M., Cutler, S. 2007. Dispersion of Wood Microfibers in a Matrix of Thermoplastic Starch and Starch–Polylactic Acid Blend. J. Biobased Mater. Bioenergy. Vol. 1: p.71-77. 7p. (Refereed)

13. Zhao, Y., Chow, T.F., Puckrin, R.S., Alfred, S.E., Korir, A.K., Larive, C.K., Cutler, S.R. 2007. Chemical genetic interrogation of natural variation uncovers a molecule that is glycoactivated. Nature Chemical Biology. Vol. 3: 11 p.716-720. 5p. (Refereed)

14. Rojas-Pierce, M., Titapiwatanakun, B., Sohn, E.J., Fang, F., Larive, C.K., Blakeslee, J., Cheng, Y., Cutler, S.R., Peer, W.A., Murphy, A.S., Raikhel, N.V. 2007. Arabidopsis P-Glycoprotein19 Participates in the Inhibition of Gravitropism by Gravacin. Chemistry and Biology. Vol. 14: p.1366-1376. 11p. (Refereed)

15. Bassel, G.W., Fung, P., Chow, T., Foong, J.A., Provart, N.J., Cutler, S.R. 2008. Elucidating the Germination Transcriptional Program
Using Small Molecules. PLant Physiology. Vol. 147: p.143-155. 13p. (Refereed)